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ag85a b c  (Mimetics)

 
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    Structured Review

    Mimetics ag85a b c
    Ag85a B C, supplied by Mimetics, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/ag85a+b+c/ag85a+b+c/pmc13118408-5-4-2
    Average 86 stars, based on 1 article reviews
    ag85a b c - by Bioz Stars, 2026-09
    86/100 stars

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    Related Articles

    Inhibition:

    Article Title: Revisiting the Antigen 85 Complex as a Target for Functional Antibody-Based Strategies Against Mycobacterium tuberculosis
    Article Snippet: Tetrahydrolipstatin (THL, Orlistat) , Ag85A and Ag85C , Covalent binding to catalytic serine in active site , Blocks mycolyl transfer reactions; reduces mycolate incorporation , Structural data confirm active-site targeting and covalent inhibition , Provides reference for direct catalytic inhibition; contrasts with potential steric/allosteric nanobody effects , [ ] . .. Trehalose analogs/substrate mimetics , Ag85A/B/C , Competitive inhibition via mimicry of TMM or trehalose substrates , Interferes with TDM formation and substrate processing , Indicates accessibility of substrate-binding groove , Suggests targeting of substrate-binding regions by nanobodies , [ ] . .. Broad-spectrum cell wall inhibitors affecting mycolate pathways , Indirect effect on Ag85 (via substrate availability) , Disruption of mycolic acid biosynthesis upstream of Ag85 , Alters substrate pool and cell wall composition , Functional coupling between biosynthesis pathways , Highlights importance of indirect modulation and substrate dynamics , [ , ] .



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